On the application of resonant absorption of radio frequency field energy in magnetic hyperthermia

Author: Giorgi Mchedlishvili
Co-authors: A. Ugulava, G. Mchedlishvili, O. Kharshiladze
Keywords: magnetic hyperthermia, magnetic nanoparticls
Annotation:

On the application of resonant absorption of radio frequency field energy in magnetic hyperthermia A. Ugulava, G. Mchedlishvili, O. Kharshiladze e-mail: giorgi.mchedlishvili@tsu.ge Physics department, Faculty of exact and natural sciences, Tbilisi State Universiti, Tbilisi, Chavchavadze av. 3 Ferrofluids are attracting attention in various fields of biomedicine and especially in hyperthermia. Magnetic nanoparticles, delivered inside a tumor in the form of a suspension, can create conditions for absorbing the energy of an alternating magnetic field. A characteristic feature of most magnetic materials is the presence of a hysteresis cycle. The energy of the alternating magnetic field, which reaches the nanoparticles through the hysteresis cycle, is converted into heat in the environment. This is a common mechanism for tumor heating during hyperthermia. In this work, it is proposed to use a different, in particular, resonance, method of exposing a system of nanoparticles to an alternating field to heat a tumor. Using the fluctuation-dissipation theorem, the power of the radio frequency field is calculated. This power is converted into heat and absorbed. In this article, it has been shown that for certain field parameters, it is possible to increase the temperature of a tumor by 6 degrees (enough to destroy malignant cells) in 15 minutes.